Mobilização neural como recurso terapêutico na recuperação funcional e morfológica do nervo ciático de ratos após lesão traumática

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The present study examined the effects of Neural Mobilization (NM) in the functional sensory-motor recovery after sciatic nerve crush injury in rats. The nerve crush was performed on adult male rats, submitted to 15 sessions of passive neural mobilization treatment through a modified straight leg raise (SLR) test, with groups starting at 3 different times:1, 5 and 10 days (NM1d, MN5d, MN10d) after nerve crush injury. Over the treatment period, sensory-motor recovery was monitored weekly using the Sciatic Functional Index (SFI), Static Sciatic Index (SSI), von Frey and acetone drop tests. Histological and morphometric nerve analyses were performed, at the end of the treatment, to assess the sciatic nerve regeneration. The results showed that early NM treatment (NM1 day) accelerated the processes of the sciatic nerve regeneration and reduced the nociceptive response (mechanical allodynia). As regarding to the late treatments (NM5 and NM10 days), these groups only showed a reduction in the nociceptive response produced by the nerve lesion but not changes in motor function. At the distal portion of the sciatic nerve, the NM1d group showed an increased average myelin sheath thickness, furthermore, the NM5d group showed a greater density of myelinated fibers. These data provide evidence that early neural mobilization treatment induced two beneficial effects: an improvement in functional recovery and reduction of mechanical allodynia, however, the late treatment (MN5d and MN10d) only had effect in reducting the nociceptive response (mechanical allodynia).

ASSUNTO(S)

neurofisiologia nervo ciatico - regeneração nervosa fisioterapia rato como animal de laboratorio

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