Deficiencia de glicose-6-fosfato desidrogenase (G-6-PD) em doenças falciformes
AUTOR(ES)
Sara Teresinha Olalla Saad
DATA DE PUBLICAÇÃO
1987
RESUMO
Glucose-6-phosphate dehydrogenase (G-6-PD) was studied in 54 male patients. From these, 31 presented sickle cell anemia(SS), 14 presented sickle cell-hemoglobin C disease(SC) and nine had S thalassemia(SS). G-6-PD was determined, before and after the reduction of the reticulocytes number, by the fluorescence test and by the measurement of enzyme activity. AlI blood samples were also analyzed by electrophoresis in cellulose acetate. After the reduction of reticulocytes, G-6-PD deficiency was detected by the fluorescence test in seven patients(3SS, 3SC, lSß). However, before the reduction of reticulocytes, this deficiency was detected in three patients only (2SC, lSß). No significant differences in G-6-PD activity were observed among the three groups studied. The enzyme activity ln these patients was significantly high~r than in patients with other hemolytic anemias(pASSUNTO(S)
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=000048656
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