Is there an association between periodontal pathogens colonization and the frequency of some specific serotype of Aggregatibacter actinomycetemcomitans? / Existe uma associação entre a colonização de patógenos periodontais e a frequência de sorotipos específicos de aggregatibacter actinomycetemcomitans?

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

30/03/2012

RESUMO

Aggregatibacter actinomycetemcomitans is a gram-negative, facultative anaerobic coccobacillus bacterium that colonizes the human oral cavity. Regarding the bacterial consortium found into biofilms, previous studies have suggested that the occurrence of particular serotypes of A. actinomycetemcomitans may be related to other oral microorganisms. Interestingly, the relations among these bacterial species seem to be under influence of geographic and ethnical aspects. Objective: This study aimed to evaluate the frequency of A. actinomycetemcomitans serotype-specific antigens and its association with Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Campilobacter rectus in Brazilian subjects. Method: A wide group of subjects (n=1320) had their periodontal status determined and were screened for the subgingival presence of A. actinomycetemcomitans serotypes. Then, a total of 263 individuals A. actinomycetemcomitans positive for serotypes A, B, C and E were considered in this survey. Subsequently, in this same group of positive subjects, the presence of P. gingivalis, P. intermedia, T. forsythia and C. rectus from periodontal pockets were also evaluated by PCR. Result: Out of 263 subjects investigated, A. actinomycetemcomitans serotype A was detected in 28.5% subjects; serotype B in 15.97%; serotype C in 51.71% and serotype E in 3.80% subjects. The frequency of serotype A of A. actinomycetemcomitans was significantly higher in C. rectus positive subjects than in P. gingivalis, P. intermedia or T. forsythia positive subjects. Additionally, the frequency of serotypes B and C were significantly higher in both C. rectus and T. forsythia positive subjects in comparison to P. gingivalis and P. intermedia positive subjects. Meanwhile, the frequency of serotype E was not associated with the presence of the other periodontal pathogens investigated. Conclusion: We observed a positive association between A. actinomycetemcomitans serotypes A with C. rectus and between B and C serotypes with C. rectus and T. forsythia.

ASSUNTO(S)

periodontitis microbiology biofilms bacterial dna periodontite actinobacillus actinomycetemcomitans microbiologia biofilmes dna bacteriano periodontia

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