Failure to demonstrate mutations affecting protein structure or function in children with congenital defects or born prematurely.
AUTOR(ES)
Neel, J V
RESUMO
An effort has been made to confirm the report [Dubinin, N. P. & Altukhov, Y. P. (1979) Proc. Natl. Acad. Sci. USA 76, 5226-5229] that children born prematurely or exhibiting congenital defects can be shown to exhibit relatively high frequencies of rare (nonpolymorphic) electrophoretic variants of proteins and that a large proportion of these variants are due to mutation in either the father or the mother. In a series of 178 children who were comparable with those described in the earlier report, we failed to encounter a high frequency of these variants in some 5341 determinations involving 45 proteins, nor were any mutations observed. Data from 1583 determinations of enzyme activity on a subset of the panel of proteins were also unremarkable. We are thus unable to confirm the earlier report.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=391733Documentos Relacionados
- Ethnic origin and lung function of infants born prematurely.
- Congenital Defects among Children Born to Women under Supervision or Treatment for Pulmonary Tuberculosis
- Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report.
- Extracardiac defects in children with congenital heart disease.
- Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.