Influencia da betametasona, empregada na forma de preparações farmaceuticas distintas, sobre alguns valores de auto-hemostasia, em ratos

AUTOR(ES)
DATA DE PUBLICAÇÃO

1992

RESUMO

The aim of this paper was to study the effeets of two distinet pharmaceutieal preparations of betamethasone, values of auto-hemostasis. To do so, 30 male Wistar rats were used, divided in 3 upon the experimental groups, dissodium phosphate betametasone acetate. Treated with normal saline, betametasone or with this salt associated with After 1, 24, 48 and 168 hours of these distinct treatments, blood samples were obtained and avaliated the clotting time and platelet count.The results showed no interference of the betamethasone Dissodium phosphate (0,1 mg / kg) , In the values of the auto-hemostasis parameters studied. In the animals treated with the depot preparati ns of betamethasone, there was a discret increase of the c clotting time and a little decrease of the platelet count, in the times of 168 and 24 hours, respectively. In spite of this alterations are statisticaly significant (p <0,05), these values are situated in biological normal ranges for the clotting time and platelet count, in rats

ASSUNTO(S)

sangue - coagulação hemostase farmacologia dentaria

ACESSO AO ARTIGO

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