Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania
AUTOR(ES)
Stertz, Laura, Fries, Gabriel Rodrigo, Aguiar, Bianca Wollenhaupt de, Pfaffenseller, Bianca, Valvassori, Samira S., Gubert, Carolina, Ferreira, Camila L., Moretti, Morgana, Ceresér, Keila M., Kauer-Sant'Anna, Márcia, Quevedo, João, Kapczinski, Flavio
FONTE
Rev. Bras. Psiquiatr.
DATA DE PUBLICAÇÃO
10/12/2013
RESUMO
Objective: In the present study, we aimed to examine the effects of repeated D-amphetamine (AMPH) exposure, a well-accepted animal model of acute mania in bipolar disorder (BD), and histone deacetylase (HDAC) inhibitors on locomotor behavior and HDAC activity in the prefrontal cortex (PFC) and peripheral blood mononuclear cells (PBMCs) of rats. Moreover, we aimed to assess brain-derived neurotrophic factor (BDNF) protein and mRNA levels in these samples. Methods: We treated adult male Wistar rats with 2 mg/kg AMPH or saline intraperitoneally for 14 days. Between the 8th and 14th days, rats also received 47.5 mg/kg lithium (Li), 200 mg/kg sodium valproate (VPT), 2 mg/kg sodium butyrate (SB), or saline. We evaluated locomotor activity in the open-field task and assessed HDAC activity in the PFC and PBMCs, and BDNF levels in the PFC and plasma. Results: AMPH significantly increased locomotor activity, which was reversed by all drugs. This hyperactivity was associated with increased HDAC activity in the PFC, which was partially reversed by Li, VPT, and SB. No differences were found in BDNF levels. Conclusion: Repeated AMPH administration increases HDAC activity in the PFC without altering BDNF levels. The partial reversal of HDAC increase by Li, VPT, and SB may account for their ability to reverse AMPH-induced hyperactivity.
Documentos Relacionados
- Brain-derived neurotrophic factor (BDNF) : possíveis implicações diagnósticas nos quadros depressivos
- The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults
- Association of serum brain-derived neurotrophic factor (BDNF) and tumor necrosis factor-alpha (TNF-α) with diagnosis of delirium in oncology inpatients
- Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients
- Different levels of brain-derived neurotrophic factor and cortisol in healthy heavy smokers