Grandisin caused morphological changes larval and toxicity on Aedes aegypti
AUTOR(ES)
Leite, Ana Carolina C. F., Kato, Massuo J., Soares, Renata O. A., Guimarães, Anthony E., Santos-Mallet, Jacenir R., Cabral, Marise M. O.
FONTE
Revista Brasileira de Farmacognosia
DATA DE PUBLICAÇÃO
24/01/2012
RESUMO
Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization.
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