Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses

Silva, Aline Correa da, Brass, Karin Erica, Loreto, Elgion da Silva, Vinocur, Myriam Elizabeth, Pozzobon, Ricardo, Azevedo, Marcos da Silva

Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses

AUTOR(ES)

Silva, Aline Correa da, Brass, Karin Erica, Loreto, Elgion da Silva, Vinocur, Myriam Elizabeth, Pozzobon, Ricardo, Azevedo, Marcos da Silva

FONTE

Genetics and Molecular Biology

DATA DE PUBLICAÇÃO

17/06/2011

RESUMO

The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.