Evaluación preclínica y estudio de estabilidad de extractos a partir del follaje de Momordica charantia Lin

AUTOR(ES)

Lagarto, A., Sánchez, E., Piloto, J., Remigio, A., Barzaga, P., Rodríguez, C., Carballo, C., Couret, M., Vega, Y., López, R

FONTE

Rev. bras. plantas med.

DATA DE PUBLICAÇÃO

2014-12

RESUMO

The objective of this investigation was the preclinical evaluation and the stability study of the Momordica charantia Linn hydroalcoholic and aqueous leaf extracts. The hydroalcoholic and aqueous extracts were obtained and the quality specifications were determined by evaluating three lots. The stability of the extracts was evaluated for 12 months. The genotoxic potential of the extracts was evaluated by mouse bone marrow micronucleus test and chromosome aberration test. The hypoglycemic effect was determined by oral glucose tolerance test. As results, the quality specifications were established and the aqueous extract was stable for 6 months and the hydroalcoholic extract for 12 months. A genotoxic effect was not observed in both extracts and the hypoglycemic effect was observed at the oral dose of 450 mg/kg of body weight.

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