Estudo da herdabilidade em genealogias de familias com portadores de psoriase cutanea e lingua geografica

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

Psoriasis is a chronic cutaneous disease whose oral condition is more frequently associated to benign migratory glossitis. Aspects as epidemiological association, basic lesions and microscopic characteristics similarly support the idea that benign migratory glossitis is the true form of oral psoriasis. This study was done having the objective of study the heritability to cutaneous psoriasis and benign migratory glossitis through the genealogy of family with holder these diseases. Were studied 356 heredograms of patients from the records of the dermatological ambulatory, independently of age, gender or ethnic group. The sample was made up of 128 propositi with cutaneous psoriasis and 257 with benign migratory glossitis. The patients suffering from cutaneous psoriasis presented benign migratory glossitis simultaneous or not and the patients of benign migratory glossitis group presented or not psoriasis simultaneously. To determination of heritability were applied Falconer?s methods. This method was developed in quantitative genetics to analyze the behavior of threshold characteristics. It was applied to date of the incidence of the diseases, so as to answer the question about the role of the inheritance and environmental factors in development the psoriasis and benign migratory glossitis. The following constations were taking from the observed results: a) the heritability of parents in families with patients suffering from cutaneous psoriasis was 89,2%, being considered high; b) high heritability was observed to sons (86,8%) and daughters (84,4%) from propositi; c) it was verified heritability higher in groups of brothers and sisters than groups of parents from propositi, that showed high heritabilities; d) the heritabities of sisters (97%) and brothers (98%) were the higher obtained, and very similar among these and higher than parents from propositi (89,2%); e) it was verified the correlation among sons/propositi (86,8%) and daughters/propositi (84,4%), both having high heritability and very similar; f) beside to benign migratory glossitis, observed that value to heritability sons/propositi (80,2%) was high than parents/propositi (41,6%), being the same verified beside to heritability daughters/propositi (68,6%) that to heritability parents/propositi (41,6%); g) the heritability brothers/propositi (56,8%) was higher than the value to parents/propositi (41,6%) and sisters/propositi (41,6%); h) beside the heritabilities sons/propositi (80,2%) and daughters/propositi (68,6%), it was observed that the heritability was higher in first than second; i) it was observed heritability higher beside brothers/propositi (56,8%) than sisters/propositi (41,6%); j) the total heritability to group with cutaneous psoriasis indicated high heritability (92,6%); k) comparing to group with benign migratory glossitis was also observed a high heritability (54,8%). These data allow the conclusion that, both psoriasis and benign migratory glossitis have a determinant genetic factor.

ASSUNTO(S)

glossitis benign migratory glossite migratoria benigna

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