Is energy expenditure in the hamster primarily under homeostatic or circadian control?

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1. In order to discriminate between homeostatic and circadian control of energy expenditure, this paper considers whether a shorter circadian cycle will produce a proportional reduction in energy expenditure (so that expenditure per unit time is conserved) or alternatively whether energy expenditure will be compressed into the shorter cycle (so that energy expenditure per cycle is conserved). To answer this question, we measured energy expenditure in tau mutant hamsters (whose free-running circadian period has been reduced to about 20 h by a single gene mutation) and wild-type hamsters (whose free-running circadian period is about 24 h). 2. In one experiment, the circadian rhythm of running-wheel activity of tau mutant hamsters was compared with that of wild-type hamsters. The rate of running was not affected by the mutation and, consequently, the total amount of activity per cycle was significantly less in mutants than in wild-type hamsters, whereas the total amount of activity per unit time was nearly the same. 3. In a second experiment, we measured energy expenditure by indirect calorimetry. Metabolic rate was not affected by the mutation and, consequently, the total amount of energy expended per cycle was significantly less in mutants than in wild-type hamsters but equivalent per unit time. 4. Because the amount of energy expenditure and locomotor activity was found to be proportional to the circadian cycle, we conclude that expenditure per unit time-rather than expenditure per circadian cycle-is conserved in the mutant animals. Therefore, we infer that energy expenditure in hamsters is primarily under homeostatic, not circadian, control. Further research is necessary to determine whether this inference can be applied to other species.

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