Efeito da finasterida e da doxazosina sobre a próstata de rato : análise ultra-estrutural e da expressão dos colágenos tipo I e III e do TGF-b 1 / Finasteride and doxazosin effects on rat prostate : ultrastructural and type Iand type III and TGF-1 expression analyses

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

Finasteride and doxazosin are drugs used in the benign prostatic hyperplasia (BPH) treatment and, more recently, they re have been used in the prostate cancer (PCa) chemoprevention, mainly because their apoptotic effect in the prostatic epithelial cells. However, few attentions have been given to the effects of these drugs in the glandular stroma. Thus, the objective of this study was to analyze the effects of the finasteride or doxazosin treatment on stroma arrangement and on specific components, like collagen type I, collagen type III and TGF-Beta 1. For this aim, we have used morphological, biochemical and molecular approaches. Finasteride treatment provoked epithelial apoptosis, epithelial basal membrane and smooth muscle cells basal membrane alterations, besides decrease the type I and type III collagen fibers expression. The alpha-adrenergic blockade increased the elastic fibers system, promoted apoptosis in epithelial cells, as well altered the type I and type III collagen fibers expression. Both drugs influenced the TGF-Beta 1 up-regulation that show to be related with apoptosis in finasteride treatment and with collagen fibers alterations and fibroblasts activation in doxazosin treatment. In conclusion, the stromal alterations promoted by finasteride and doxazosin treatments can contribute to the prostate regression expected in the BPH treatment and to the rupture of paracrine events responsible by tumoral evolution in the PCa

ASSUNTO(S)

prostata matriz extracelular finasterida doxazosina colageno elastina prostate extracellular matrix finasteride doxazosin collagen

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