Determination of 3,4-methylenedioxymethamphetamine (MDMA - Ecstasy), 3,4-methylenedioxyethylamphetamine (MDEA - Eve) and 3,4-methylenedioxyamphetamine (MDA) in biological fluids by high-performance liquid chromatography: forensic aspect / Determinação de 3,4-metilenodioximetanfetamina (MDMA - Ecstasy), 3,4-metilenodioxietilanfetamina (MDEA - Eve) e 3,4-metilenodioxianfetamina (MDA) em fluidos biológicos por cromatografia líquida de alta eficiência: aspecto forense

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

There is a worldwide increase in the use of the synthetic drugs of abuse known as designer drugs. The main representatives of this class are Ecstasy or 3,4-methylenodioxymethamphetamine (MDMA) and Eve or 3,4- methylenodioxyethylamphetamine (MDEA), substances with stimulant and hallucinogenic effects. In Brazil media coverage of them is on the increase and their recreational is in evidence by the growing numbers of patients who seek treatment at drug treatment centers. This paper validates the analytical methodology for the laboratory diagnosis of the use of MDMA, MDEA and their product of biotransformation, 3,4-methylenodioxyamphetamine (MDA), in whole blood and urine by high performance liquid chromatography with fluorescence. The developed methods showed good linearity, precision, accuracy, yield and capacity to detect analytes even when present in low concentrations, which enables its application in cases high intoxication as well as in cases of the recreational use of these drugs of abuse.

ASSUNTO(S)

drogas de abuso forensic toxicology toxicologia forense cromatografia líquida de alta eficiência análise toxicológica ecstasy mdea high performance liquid chromatography hplc ecstasy mdma analytical toxicology mda drugs of abuse

ACESSO AO ARTIGO

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