Cytotoxic tirucallane triterpenes from the stem of Luvunga scandens
AUTOR(ES)
Al-Zikri, Putri Nur Hidayah, Taher, Muhammad, Susanti, Deny, Rezali, Mohamad Fazlin, Read, Roger W., Sohrab, Md. Hossain, Hasan, Choudhury Mahmood, Ahmad, Farediah
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2014-10
RESUMO
Two tirucallane triterpenes, namely flindissol (1) and 3-oxotirucalla-7,24-dien-21-oic-acid (2), were isolated from the dichloromethane extract of the stem of Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae. This is the first report of their isolation from this plant. Their structures were constructed by high resolution mass and 2D NMR spectroscopic data. The cytotoxic potential of the two pure compounds 1 and 2 were determined by MTT assay against human breast adenocarcinoma cell line (MCF-7). Compounds 1 and 2 showed potent cytotoxicity against MCF-7 cell line with IC50 values of 13.8 μM and 27.5 μM, respectively. This result suggested their potential activity as antitumor agents.
Documentos Relacionados
- Friedelane Triterpenes with Cytotoxic Activity from the Leaves of Maytenus quadrangulata (Celastraceae)
- Pentacyclic triterpenes from branches of Maytenus robusta and in vitro cytotoxic property against 4T1 cancer cells
- Lanostane triterpenes from the fungus Pisolithus tinctorius
- Triterpenes from the flowers of Gochnatia polymorpha subsp. floccosa
- Triterpenes and flavonoids from the roots of Mauritia flexuosa