Contribution to the phytochemical study of the species Capraria biflora L. (Scrophulariaceae) / ContrÃbuiÃÃo ao estudo fitoquÃmico da espÃcie Capraria biflora L. (Scrophulariaceae)

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

22/07/2011

RESUMO

This paper describes the reinvestigation phytochemical of the fixed constituents present in the roots and stems of the species Capraria biflora, of the family Scrophulariaceae, as well as research on the chemical composition of essential oil extracted from the leaves and evaluates the larvicidal activity against Aedes aegypti larvae. The study of the essential oil resulted in the identification of seven constituents among which six are sesquiterpene compounds. The essential oil was tested for larvicidal activity and showed a moderate activity, with LC50 = 73.39. Chromatographic studies on silica gel, petroleum ether extract of the roots and ethanol of stems, allowed the isolation and characterization of four compounds: the naphthoquinone biflorin, the sesquiterpene caprariolide B, sugar D-mannitol and iridoid miopoclorin, unprecedented in kind. The structure of the compounds was performed by spectrometric techniques: infrared (IR), mass spectrometry (MS) and nuclear magnetic resonance of hydrogen (1H) and carbon-13 (13C NMR), including two-dimensional techniques (COSY, HSQC and HMBC) and comparison with data reported in the literature.

ASSUNTO(S)

quimica dos produtos naturais quÃmica vegetal scrophulariaceae capraria biflor

ACESSO AO ARTIGO

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