COMPARISON OF MAGNETIC RESONANCE IMAGING AND HISTOPATHOLOGY IN ESTIMATED HEPATIC IRON OVERLOAD IN PATIENTS WITH SICKLE CELL DISEASE. / COMPARAÇÃO ENTRE RESSONÂNCIA MAGNÉTICA E HISTOPATOLOGIA NA ESTIMATIVA DA SOBRECARGA DE FERRO HEPÁTICO EM PORTADORES DE ANEMIA FALCIFORME.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

The aim of this cross-sectional study was to compare MRI with liver biopsy as a tool for identification and quantification of liver iron overload in patients with sickle cell anemia using blood transfusions. We compared the results of the baseline serum ferritin in the absence of acute complications, the estimated liver iron concentration by magnetic resonance imaging and semiquantitative determination of iron in a fragment of liver tissue obtained by percutaneous biopsy. We observed a statistically significant correlation (r = 0.75) between the degree of iron overload identified in a fragment of liver tissue (Scheuer criteria) and the estimated mean concentration of iron calculated from the intensity of the signal detected by MRI (p = 0.0007). This relationship persists when we aggregate the results in two groups: without or minimal overload (Scheuer zero and one) and presence of overload (Scheuer 2- 4), p = 0.004. MRI was able to differentiate patients with and without iron overload when compared with histological data. MRI is a non-invasive method and can be used to replace liver biopsy for monitoring patients with sickle cell anemia when there is no associated liver disease. To date, this is the first study to make this assessment in patients with sickle cell anemia.

ASSUNTO(S)

anemia falciforme transfusão de eritrócitos ferritina imagem por ressonância magnética biópsia/fígado medicina sickle cell anemia erythrocyte transfusion ferritin magnetic resonance imaging biopsy/liver.

ACESSO AO ARTIGO

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