Colon myoelectric activity in rats under different hormonal status. Influence of high levels of estrogen, progesterone and pregnancy. Experimental study in vivo / A atividade mioelétrica colônica em ratas sob diferentes estados hormonais: influência de altos níveis de estrógeno, progesterona e da prenhez: estudo experimental in vivo
AUTOR(ES)
Léa Beltrão de Medeiros Speranzini
DATA DE PUBLICAÇÃO
2006
RESUMO
The aim of this study was to find out if the hormonal complex of pregnancy, especially progesterone, could be responsible for decreasing colon myoelectric activity in female rats. We analyzed the records of colon myoelectric activity in vivo using the method of musculoserosal implantation of electrodes in four regions of the colon: proximal ascendent colon, distal ascendent colon, medial colon and descendent colon. The rats were divided in five groups: control, ovariectomized, ovariectomized and treated with estrogen, ovariectomized and treated with progesterone and pregnant rats. The results showed a greater electric activity in the proximal colon in pregnant and progesterone pretreated rats. In pregnant rats the duration of maximum electric activity was significantly greater in all distances studied. The results suggest that in vivo progesterone and the hormonal complex of pregnancy increase myoelectric activity of the proximal colon, and that pregnancy increases the duration of the maximum electric activity of the colon in every distance studied leading to more dehydrated fecal material. Progesterone and pregnancy should not be responsible for colon hypomotility, one of the hypothesis that could explain intestinal constipation in pregnant women
ASSUNTO(S)
colon electrodes pregnancy estrogênios cólon rats wistar estrogens progesterone ratos wistar eletrodos progesterona prenhez animal
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