Clonagem e expressão gênica de antígenos candidatos vacinais contra leptospirose. / Cloning and gene expression of vaccinal candidates against leptospirosis.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

26/03/2012

RESUMO

Leptospirosis is an infectious disease that affects domestic animals, wildlife and humans, caused by bacteria of the genus Leptospira. In Brazil, pulmonary hemorrhage is the major risk factor to death with mortality rates for this form of the disease over than 50%. Thus, the development of a preventive vaccine and better understanding of injury mechanisms involved in leptospirosis would allow us to propose new therapies to reduce the high mortality associated with the disease. In the present study we proposed to investigate twelve genes of Leptospira interrogans serovar Copenhageni. The identification of one protease opens the way for the investigation of a possible protease involved in bleeding processes in this important zoonosis. With the results presented here, we expect to contribute to the biology and pathogenicity characterization of leptospirosis.

ASSUNTO(S)

leptospirose leptospirosis proteínas recombinantes recombinant proteins vaccines vacinas

ACESSO AO ARTIGO

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