Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
AUTOR(ES)
Lambertucci, José Roberto, Fidelis, Thiago André, Pereira, Thiago Almeida, Coelho, Paulo Marcos Zech, Araujo, Neuza, Souza, Márcia Maria de, Brasileiro Filho, Geraldo, Pereira, Fausto Edmundo Lima, Antunes, Carlos Mauricio
FONTE
Rev. Soc. Bras. Med. Trop.
DATA DE PUBLICAÇÃO
12/02/2014
RESUMO
Introduction Human neuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. Methods In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. Results S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. Conclusions This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S. mansoni. An investigation of experimental neuroschistosomiasis is now feasible.
Documentos Relacionados
- Metabonomic investigations in mice infected with Schistosoma mansoni: An approach for biomarker identification
- Isolated hepatic granulomas from mice infected with Schistosoma mansoni contain nerve growth factor.
- Sm14 of Schistosoma mansoni in Fusion with Tetanus Toxin Fragment C Induces Immunoprotection against Tetanus and Schistosomiasis in Mice
- Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice
- Hepatic stereology of schistosomiasis mansoni infected-mice fed a high-fat diet
