Avaliação da atividade tipo ansiolítica do óleo essencial das folhas de Spiranthera odoratissima A. St. Hil. - possível mecanismo envolvido / Anxiolytic-like activity of essential oil from Spiranthera odoratissima A. St. Hil. leaves possible mechanism evolved

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

28/02/2011

RESUMO

Anxiety is among the most common chronic disease in the world. In Brasília city (capital of Brazil), anxiety disorders affect 12.1 % of population and are the most prevalent psychiatry disease. Since the introduction of benzodiazepines in the 1960s, they have been the most commonly prescribed treatment for anxiety disorders. However, their side-effects such as sedation, myorelaxation, ataxia, amnesia, and pharmacological dependence are prominent. Thus, new therapies are necessary in the treatment of anxiety di-sorders and the study of medicinal plants could provide new therapeutic options. Spiranthera odoratissima A. St. Hillaire (Rutaceae), popularly known in Brazil as manacá, is a shrub found in the Brazilian Cerrado region. It is used in folk medicine to treat renal and hepatic diseases, stomachache, headaches and rheumatism. The aim of this work was to evaluate the pharmacological activity of essential oil from S. odoratissima leaves (EO) on the CNS activities in mice, with special attention to an anxiolytic-like effect as well as the underlying mechanism involved. EO increased the crossing of central areas and time spent in central area without altering the locomotor parameters in the open field and rota-rod tests. In the pentobarbital-induced sleep, EO decreased the latency and increased the sleeping time. In the anxiety paradigms, EO also increased the number of head-dipping behaviors in the hole-board test, the entries and time spent on open arms in the elevated plus maze test (EPM), and the number of transitions and time spent in the light compartment on the light-dark box test (LDB). We further investigated the anxiolytic-like mechanism of EO by pre-treating animals with antagonists of benzodiazepine (flumazenil) and 5HT1A (NAN-190) receptors on the EPM and LDB. The anxiolytic-like effect of EO was only blocked by NAN-190, but not by flumazenil. In conclusion, these results suggest that the essential oil from S. odoratissima produces anxiolytic-like effect without altering the motor parameters, and probably acts via 5HT1A receptor but not via GABAA/benzodiazepine receptor. NOTE: As programs do not copy or copy with some formatting errors, clik PDF - dissertation at the bottom of the screen.

ASSUNTO(S)

spiranthera odoratissima manacá atividade farmacológica atividade tipo ansiolítica farmacologia spiranthera odoratissima; manacá; atividade farmacológica; atividade tipo ansiolítica spiranthera odoratissima manacá pharmacological evaluation anxiolytic-like activity

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