Atividade antifúngica dos óleos essenciais de espécies de Ocimum frente a cepas de Candida SPP. E Microsporum canis. / Antifungal activity of essential oils of Ocimum species against strains of Candida SPP. And Microsporum canis.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

29/07/2009

RESUMO

Due to high incidence of infections caused by fungi and resistance to antifungal agents of these microorganisms, the growing importance of studies on bioprospecting of natural products with antimicrobial properties and potential phytotherapic. This study aimed at finding new antifungal agents from the essential oils of Brazilian species Ocimum. The essential oils from the leaves of Ocimum americanum, O. basilicum var. purpurascens, O. basilicum var. minimum, O. micranthum and O. selloi were obtained by steam distilled and analyzed by gas chromatography/mass spectrometry. The antifungal activity of essential oils was evaluated against strains of Microsporum canis, Candida albicans, C. tropicalis, C. parapsilosis, C. glabrata and C. krusei by the method of microdilution in broth. Chemical analysis showed that the main components were (Z)-methyl cinnamate and 1,8-cineole for O. americanum, linalool and α-muurulol for O. basilicum var. purpurascens, linalool and estragole for O. basilicum var. minimum, e-caryophyllene and eugenol for O. micranthum and linalool and 1,8-cineole for O. selloi. The evaluation of antifungal activity showed that the O. basilicum var. minimum essential oil was active only against strains of M. canis. O. basilicum var. purpurascens essential oil was active against strains of M. canis, C. albicans and C. parapsilosis and O. americanum inhibited the strains of M. canis, C. albicans, C. parapsilosis and C. tropicalis. O. micranthum and O. selloi essential oils were active against all strains tested. O. micranthum showed the lowest values of MIC, ranging from 312.5 to 1200 mg ml-1. Considering the above, the essential oils of O. americanum, O. basilicum var. purpurascens, O. micranthum and O. selloi were active in vitro against Candida spp. and M. canis and is promising as sources for the development of new agents for herbal treatment of mycoses.

ASSUNTO(S)

ocimum ssp atividade antifúngica candida ssp microsporum canis reproducao animal ocimum spp antifungal activity candida spp microsporum canis

ACESSO AO ARTIGO

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