Anxiolytic-like effects of erythrinian alkaloids from erythrina suberosa
AUTOR(ES)
Serrano, Maria Amélia Rodrigues, Batista, Andrea Nastri de Luca, Bolzani, Vanderlan da Silva, Santos, Luciana de Ávila, Nogueira, Paulo José de Campos, Nunes-de-Souza, Ricardo Luiz, Latif, Abdul, Arfan, Mohammad
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2011
RESUMO
Two alkaloids, erysodine (1) and erysothrine (2) were isolated from the flowers of a Pakistani medicinal plant, Erythrina suberosa. These compounds were investigated for anxiolytic properties, and the results showed significant effect, in an acute oral treatment with 1-2, which were suspended in saline (NaCl 0.9%) plus DMSO 1%, and evaluated in 122 Swiss male mice exposed to two tests of anxiety - the elevated plus-maze (EPM) and the light/dark transition model (LDTM).
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