Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus

AUTOR(ES)

Toblli, Jorge E.

FONTE

Oxford University Press

RESUMO

Background. Recent evidence suggests that treatment of type 2 diabetes with thiazolidinediones [peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists], ameliorates glomerulosclerosis and tubulointerstitial fibrosis in the rat kidney. In the current work, we have investigated whether these drugs, and specifically pioglitazone (PGT), act by preventing fibrosis and kidney dysfunction mainly through antioxidant and anti-inflammatory effects, independently of glycaemic control.

Documentos Relacionados

• Effects of Glycemic Load on Metabolic Health and Type 2 Diabetes Mellitus
• Characteristic changes in coronary artery at the early hyperglycaemic stage in a rat type 2 diabetes model and the effects of pravastatin
• Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus
• Proceedings: The kidney in diabetes mellitus.
• Efeitos da diacereína sobre a resistência à insulina em modelo animal de obesidade e diabetes mellitus tipo 2