Analise comparativa das caracteristicas microscopicas da lesão liquenoide na GVHD cronica e no liquen plano de boca

AUTOR(ES)
DATA DE PUBLICAÇÃO

2001

RESUMO

Lichen planus (LP) is a chronic mucocutaneous disease of unknown etiology, that frequently affects the oral mucosa. Microscopically, LP is characterized by areas of epithelial acantosis and atrophy, with disorganization of the basal layer, and by a subepithelial band-like mononuclear inflammatory infiltrate. Lichenoid lesion are diseases that present a similar pattern to LP, that can affect the mouth and skin, as Lichenoid lesions may be associated with chronic Graft versus Host Disease (cGVHD). The objective of this work was to compare the microscopic characteristics of LP and those of cGVHD in the oral mucosa. Epithelial and connective tissue alterations were evaluated in 40 cases of LP and in 31 cases of cGVHD, as well as the presence of mast cells, Langerhans cells (CL) and macrophages. The main differences found between the two diseases were at dermal-epithelial junction area. In LP the inflammatory infiltrate was more intense, but disorganization and vacuolization of the epithelial basal cells were less evident. Mast cells were more numerous in lichen planus, and showed less granules when observed in the inflammatory infiltrated. LC were more numerous in lichen planus and macrophages in cGVHD. The laminin expression was similar in both groups. From these observations it was concluded that lichenoid lesions of cGVHD of the oral mucosa differs from LP, particularly at the dermal-epithelial junction region. In LP the inflammatory infiltrate is more intense, but the antigenic expression possibly is less than in cGVHD, causing a more discrete epithelial cells alterations

ASSUNTO(S)

medula ossea mastocitos macrofagos imunologia de transplantes imunohistoquimica

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