Antimetabolic
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Estudo da ação do inibidor de proteinase de Adenanthera pavonina sobre o desenvolvimento e atividade das proteinases intestinais de lagartas de Diatraea suchharalis (FABR., 1794) / Study of proteinase inhibitor action from Adenanthera pavonina on the development and midgut proteinase activities of the Diatraea sachharalis larvae (FABR., 1794)
Phytophatogous insects and other animals use digestive enzymes, such as amylases and proteinases to process the nutrients obtained from the plants necessary for their development. The sugarcane borer Diatraea saccharalis is the major pest of sugarcane in Brazil and other South American countries. Plants synthesize a variety of molecules, including proteinase
Publicado em: 2008
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2. Efeito de um inibidor de tripsina de sementes de Plathymenia foliolosa sobre o desenvolvimento e atividade enzimatica de Anagasta kuehniella / Effect of a trypsin inhibitor from Plathymenia foliolosa seeds on Anagasta kuehniella development and enzymatic activity
Proteinase inhibitors (PIs) are widely distributed in animals, microorganisms, and plants. Plant PIs are generally small proteins that have mainly been described as occurring in storage tissues, such as tubers and seeds, but they have also been found in the aerial parts of plants, in the leaves, flowers and roots. The possible roles suggested for seed protei
Publicado em: 2008
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3. Mucosite intestinal experimental induzida por 5-fluorouracil: Papel de IL-1β, IL-4 e PAF e avaliaÃÃo das alteraÃÃes da motilidade digestiva / Mucositis intestinal experimental induced by 5-fuorouracil: Role IL-1β, IL-4 and PAF and evaluation of the alterations of motility gastrintestinal
Objetivos: Avaliar os mediadores inflamatÃrios e as alteraÃÃes motoras gastrintestinais no curso da mucosite intestinal experimental induzida por 5-FU. MÃtodos: Para avaliar as citocinas utilizamos camundongos balb-c ou c57/black (25-30g), tratados com IL-1Ra (100mg/Kg, i.p., diariamente) ou deficientes para IL-4 (IL-4 -/-) ou para IL-18 (IL-18 -/-). A f
Publicado em: 2008
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4. Efeito de um inibidor de proteinase serinica sobre o desenvolvimento e atividade enzimatica de Heliothis virescens (Lepidopter: Noctuidae) / Effect of a trypsin inhibitor on the development and enzymatic activity of Heliothis virescens (Lepidoptera: Noctuidae)
Proteinase inhibitor proteins (PIs) are one of the defensive chemicals produced by plants against pests and pathogens. PIs are polypeptides that are able to bind to insect midgut proteolytic enzymes, rendering them inactive by competitive inhibition. This process leads to a limitation of essential amino acids in protein synthesis, and thus, to reduction in g
Publicado em: 2007
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5. Câncer e agentes antineoplásicos ciclo-celular específicos e ciclo-celular não específicos que interagem com o DNA: uma introdução
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis inhibition), inherently reactive agents (DNA alkylating electrophilic traps for macromolecular nucleophile
Química Nova. Publicado em: 2005-02
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6. A Ciba Foundation Symposium on Amino Acids and Peptides with Antimetabolic Activity
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7. Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs.
Dihydrofolate reductase (DHFR; EC 1.5.1.3) is required in folate metabolism for the synthesis of purines, thymidine, and glycine. Although there have been several reports of induction of DHFR enzyme by methotrexate (MTX), a drug that competitively inhibits DHFR, there are no studies reported that examine the effect of MTX on DHFR gene transcription. We have
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8. Effect of Methisazone and Other Drugs on Mouse Hemopoietic Colony Formation In Vitro
Methisazone (N-methylisatin β-thiosemicarbazone) was shown to inhibit the development of hemopoietic colonies in vitro when incorporated in the culture medium. The activity of methisazone was compared with that of several antimetabolic and antibiotic drugs. Although methisazone reduced the number of colonies, it did not affect the size of those colonies whi
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9. AMINO ACID INTERACTIONS IN NEUROSPORA CRASSA
Soboren, Josephine (University of California, Los Angeles), and Joseph F. Nyc. Amino acid interactions in Neurospora crassa. J. Bacteriol. 82:20–25. 1961.—A systematic study of the effects of the naturally occurring amino acids on the growth of a wild-type strain of Neurospora crassa focused attention upon l-tryptophan, which exhibits a strong growth inh
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10. Indicator Technique for Antimetabolic Toxin Production by Phytopathogenic Species of Pseudomonas
A simple bacteriological technique involving inhibition zone production on a lawn of Escherichia coli was developed to detect antimetabolite toxin production by phytopathogenic species of Pseudomonas. It was established that the mechanism of E. coli inhibition paralleled that of phytotoxin-induced chlorosis of plant tissue. Derivatives of Pseudomonas tabaci
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11. Antiviral and antimetabolic activities of neplanocins.
Of a series of carbocyclic analogs of adenosine, in which the ribose moiety was replaced by a cyclopentenyl ring, neplanocin A, or (-)-9-[trans-2, trans-3-dihydroxy-4-(hydroxymethyl)cyclopent-4-enyl]adenine proved particularly effective in inhibiting the multiplication of DNA viruses (i.e., vaccinia), (-)RNA viruses (i.e., parainfluenza, measles, and vesicul
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12. Inhibitory effect of E-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on herpes simplex virus replication and DNA synthesis.
The effect of E-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU) on herpes simplex virus (HSV) replication was examined and compared with that of E-5-(2-bromovinyl)-2'-deoxyuridine (BVdUrd). The 50% inhibitory dose against HSV type 1 (HSV-1) was 0.1 microgram/ml compared with 0.008 microgram/ml for BVdUrd; the antimetabolic 50% inhibitory dose of BV