Antihypertensive Activity
Mostrando 1-12 de 49 artigos, teses e dissertações.
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1. Effect of pumpkin seed oil on cholesterol fractions and systolic/diastolic blood pressure
Abstract Pumpkin seed oil (PSO) is high in unsaturated fatty acids and plant sterols, which have numerous cardiovascular benefits. The study explores the hypothesis by investigating effects of consumption of 1000 mg of PSO on total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), systolic (SBP) and diastolic (DBP) blood pressu
Food Sci. Technol. Publicado em: 2020-09
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2. Essential oil of the leaves of Eugenia sulcata preserve myocardial contractility and does not present immunotoxicity
The essential oil of the leaves of Eugenia sulcata, in the Myrtaceae family, has a demonstrated antihypertensive effect, but its effects on heart muscle and its toxicity have not yet been elucidated. Little chemical or biological data are available for E. sulcata, whether emphasizing the beneficial effects or the pharmacological security of this species. Thi
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
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3. The Physical Activity Level, Body Composition and Diabetes Mellitus Influence the Association Between Depression and Hypertension in Community-Dwelling Elders
Abstract Background: Depression and hypertension are highly prevalent among elderly people. Although the relationship between these conditions is well recognized, however, the factors that may influence such association are not clearly understood. Objective: To analyze the association between depression and hypertension in community-dwelling elders. Metho
Int. J. Cardiovasc. Sci.. Publicado em: 12/08/2019
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4. Comportamentos em saúde e o controle da hipertensão arterial: resultados do ELSI-BRASIL
Resumo: O objetivo foi quantificar a contribuição de comportamentos em saúde selecionados para a prevalência do controle da hipertensão junto a adultos brasileiros com 50 ou mais anos de idade. Foram analisados os dados do ELSI-Brasil. Foram incluídos, no estudo, 4.318 indivíduos com 50 anos ou mais, que relataram ter recebido diagnóstico médico de
Cad. Saúde Pública. Publicado em: 22/07/2019
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5. Candesartan inhibits inflammation through an angiotensin II type 1 receptor independent way in human embryonic kidney epithelial cells
Abstract: Besides stimulating vasoconstriction, Angiotensin II is also well known in inducing reactive oxygen species and promoting inflammatory phenotype switch via its type 1 receptor. In clinic, Angiotensin II type 1 (AT1) receptor blocker like candesartan has been widely applied as an antihypertensive medication. We previous have demonstrated that a high
An. Acad. Bras. Ciênc.. Publicado em: 25/04/2019
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6. Augmented cytotoxic, mutagenic and genotoxic response triggered by carvedilol and celecoxib combinations
Abstract It is understood that drugs regardless of their order of administration can exhibit drug interactions. Established on the fact that treatment of hypertension may last for decades and prolong usage of multiple drug regimen may induce substantial pathophysiological changes. Hence, This study was designed to evaluate the possible synergistic toxic effe
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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7. UPLC/Q-TOF-MS profiling of phenolics from Canarium pimela leaves and its vasorelaxant and antioxidant activities
ABSTRACT Canarium pimela K.D. Koenig, Burseraceae, have a long history of use in the Chinese traditional medicine treatment of various ailments including hypertension, and our research team has reported the anti-hypertensive activity and delineated the mechanism involved in the action. The following research aims to evaluate the vasorelaxant and antioxidant
Rev. bras. farmacogn.. Publicado em: 2017-12
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8. Vasoactive Thiomethyl-Pyrimidines: Promising Drug Candidates with Vascular Activity
Pyrimidines and their derivatives are present in various biologically active molecules. Most of the synthetic methods employed to achieve the pyrimidinone ring consist of two stages: the synthesis of a Michael intermediate from an aldehyde and an "active methylene" containing compound; and the condensation of this intermediate with a molecule containing an u
J. Braz. Chem. Soc.. Publicado em: 2017-07
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9. Evaluation of mechanism for antihypertensive and vasorelaxant effects of hexanic and hydroalcoholic extracts of celery seed in normotensive and hypertensive rats
ABSTRACT Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic vegetables and part of the daily diet around the world. In this study, aqueous-ethanolic and hexane extracts of celery seed were prepared and the amount of n-butylphthalide, as an active component, was determined in each extract. Then the effects of hexanic extract on systolic, di
Rev. bras. farmacogn.. Publicado em: 2016-10
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10. Mechanisms of the antihypertensive effects of Nigella sativa oil in L-NAME-induced hypertensive rats
OBJECTIVES: This study was conducted to determine whether the blood pressure-lowering effect of Nigella sativa might be mediated by its effects on nitric oxide, angiotensin-converting enzyme, heme oxygenase and oxidative stress markers. METHODS: Twenty-four adult male Sprague-Dawley rats were divided equally into 4 groups. One group served as the control (
Clinics. Publicado em: 2015-11
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11. Peptide separation of commercial fermented milk during refrigerated storage
Milk is an important source of bioactive compounds. Many of these compounds are released during fermentation and refrigerated storage. The aim of this study was to determine the release of peptides by lactic acid bacteria in commercial fermented milk during refrigerated storage. The size and profile of peptides were analyzed by polyacrylamide gel electrophor
Food Sci. Technol. Publicado em: 2014-12
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12. A bradykinin-potentiating peptide (BPP-10c) from Bothrops jararaca induces changes in seminiferous tubules
Background The testis-specific isoform of angiotensin-converting enzyme (tACE) is exclusively expressed in germ cells during spermatogenesis. Although the exact role of tACE in male fertility is unknown, it clearly plays a critical function in spermatogenesis. The dipeptidase domain of tACE is identical to the C-terminal catalytic domain of somatic ACE (sAC
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/11/2013