Anticoagulant Activity
Mostrando 1-12 de 166 artigos, teses e dissertações.
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1. Pyrazolyl-Tetrazoles and Imidazolyl-Pyrazoles as Potential Anticoagulants and their Integrated Multiplex Analysis Virtual Screening
This article reports a novel virtual screening algorithm seeking the rational identification of novel lead anticoagulants. Seven 5-(3-methyl-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles and seven novel 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-3-methyl-1H-pyrazoles were obtained in three steps starting from arylhydrazine hydrochlorides as raw materials in good yields
J. Braz. Chem. Soc.. Publicado em: 2019-01
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2. Thrombin generation assays for global evaluation of the hemostatic system: perspectives and limitations
Abstract The existing techniques to evaluate hemostasis in clinical laboratories are not sensitive enough to detect hypercoagulable and mild hypocoagulable states. Under different experimental conditions, the thrombin generation test may meet these requirements. This technique evaluates the overall balance between procoagulant and anticoagulant forces and ha
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-09
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3. Microwave Assisted Synthesis of Novel Six-Membered 4-C, 4-O and 4-S Lactams Derivatives: Characterization and in vitro Biological Evaluation of Cytotoxicity and Anticoagulant Activity
A series of six-membered lactam derivatives containing C, O and S atoms in position 4 were synthesized using microwave methodology through coupling reactions. The novel compounds were synthesized following two step reaction to yield fifteen derivatives. The final derivative N-(4-(3-oxotiomorpholin)phenyl) hexanamide was selectively toxic to the HCT-116 cell
J. Braz. Chem. Soc.. Publicado em: 2017-02
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4. Inhibitory effects of Swietenia macrophylla on myotoxic phospholipases A2
Activity-guided fractionation of an ethanol-soluble extract of the leaves of Swietenia macrophylla King, Meliaceae, led to several fractions. As a result, sample Sm13-16, 23 had the most promising activity against phospholipases A2 (PLA2), Asp49 and Lys49 types. This fraction inhibited PLA2 activity of the Asp49 PLA2, when aggregated substrate was used. On t
Rev. bras. farmacogn.. Publicado em: 2013-12
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5. Leishmania amazonensis exhibits phosphatidylserine-dependent procoagulant activity, a process that is counteracted by sandfly saliva
Leishmania parasites expose phosphatidylserine (PS) on their surface, a process that has been associated with regulation of host's immune responses. In this study we demonstrate that PS exposure by metacyclic promastigotes of Leishmania amazonensis favours blood coagulation. L. amazonensis accelerates in vitro coagulation of human plasma. In addition, L. am
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
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6. Reversal of the anticoagulant and anti-hemostatic effect of low molecular weight heparin by direct prothrombin activation
Lopap, found in the bristles of Lonomia obliqua caterpillar, is the first exogenous prothrombin activator that shows serine protease-like activity, independent of prothrombinase components and unique lipocalin reported to interfere with hemostasis mechanisms. To assess the action of an exogenous prothrombin activator reversing the anticoagulant and antihemos
Braz J Med Biol Res. Publicado em: 2012-10
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7. Propriedades antioxidante, anti-hemostástica e antiproliferativa de galactanas sulfatadas da alga vermelha hypnea musciformis (wulfen) j. V. Lamouroux
Algas marinhas são uma das principais fontes de compostos biologicamente ativos. Na matriz extracelular desses organismos existem os polissacarídeos sulfatados que funcionam como componente estrutural prevenindo-a contra desidratação. A fração 1,0 (F1,0) rica em galactanas sulfatadas obtida da alga vermelha Hypnea musciformis foi caracterizada fisicoqu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/07/2011
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8. ATIVIDADE ANTI-INFLAMATÓRIA DE POLISSACARÍDEOS ISOLADOS DAS PLANTAS Caesalpinia ferrea E Azadirachta indica / ANTI-INFLAMMATORY ACTIVITY OF ISOLATED PLANT Polysaccharides Caesalpinia ferrea AND Azadirachta indica
Polysaccharides of higher plants form complex structures and multiple intermolecular interactions. They are noted for their immune system activities, being classified as exogenous modifiers of biological responses. However, the spectrum of activities is very large including the antiviral, antitumor, immunostimulant, anti-inflammatory, anticoagulant and antic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/03/2011
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9. Atividades antinociceptiva e antiinflamatÃria dos polissacarÃdeos sulfatados da alga marinha vermelha Gracilaria cornea J. Agardh / Antinociceptive and anti-inflammatory activities of sulfated polusaccharides from the red marine alga Gracilaria cornea J. Agardh (1852) in animals
Marine algae are natural sources of sulfated polysaccharides possessing several biological activities (anticoagulant, antithrombotic, antinociceptive, anti-inflammatory etc.) and that exhibit minimal toxicity and are considered of great interest to the pharmaceutical and food industries. This study aimed to evaluate the effects of sulfated polysaccharides to
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/02/2011
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10. Biological activities of the sulfated polysaccharide from the vascular plant Halodule wrightii
A sulfated polysaccharide (SPSG) was successfully isolated from seagrass Halodule wrightii Asch., Cymodoceaceae, and its antioxidant and anticoagulant activities were investigated. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan with a sulfatation degree of 20.63% and it also contains glucose and xylose. SPSG antioxidant acti
Revista Brasileira de Farmacognosia. Publicado em: 01/11/2011
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11. Anticoagulant activity of a sulfated polysaccharide isolated from the green seaweed Caulerpa cupressoides
The aim of this study was to evaluate certain molecular characteristics of a sulfated polysaccharide (SPs) with anticoagulant properties, isolated from Caulerpa cupressoides (Chlorophyta). Crude SPs were extracted by proteolytic digestion (papain), followed by ion-exchange chromatography on a DEAE-cellulose column. The fractions obtained were analyzed for mo
Brazilian Archives of Biology and Technology. Publicado em: 2011-08
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12. Planejamento e síntese de intermediários para a obtenção de novos candidatos a protótipos de fármacos anticoagulantes desenhados a partir da infestina-4 / Planning and synthesis of intermediates for obtaining new candidates for prototypes of anticoagulants drawn from the infestin-4
Thromboembolic disorders produce the majority of diseases affecting the heart, and are the third leading cause of death worldwide. Venous thromboembolism is a thromboembolic disorder that occurs in the venous circulation, is a disease of high prevalence and remains a major cause of morbidity and mortality in hospitalized patients undergoing major surgery, th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/09/2010