Action Potential
Mostrando 1-12 de 2847 artigos, teses e dissertações.
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1. Efficient Encapsulation and Controlled Release of N,N-Diethyl-3-methylbenzamide (DEET) from Oil-in-Water Emulsions Stabilized by Cationic Nanocellulose and Silica Nanoparticles
Oil-in-water emulsions containing N,N-diethyl-3-methylbenzamide (DEET) were developed aiming to extend the sustained release of the active compound, by using two oppositely charged nanomaterials, namely silica nanoparticles (SiNP) and cationic cellulose nanofibrils (CCNF), as stabilizers, and a mixture of food-grade nonionic surfactants to avoid precipitatio
Journal of the Brazilian Chemical Society. Publicado em: 2023
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2. In silico prediction of inhibitory potential of a punicalagin β-anomer against SARS-COV-2 main protease (MPRO)
The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts is the SARS-CoV-2 main pr
Química Nova. Publicado em: 2022
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3. AOPs são o futuro da ecotoxicologia?
ARE AOPs THE FUTURE OF ECOTOXICOLOGY? AOPs (Adverse Outcome Pathways) were introduced in the field of ecotoxicology due to the need of replacement of the classic system for assessing adverse results (considering only the mortality of organisms exposed to certain substances or mixtures) to a predictive system based on the measurement of biological events occu
Química Nova. Publicado em: 2022
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4. Vitamin C (Ascorbic acid) protects from neuropathy caused by cisplatin, through enhanced heat shock protein-70 and reduced oxidant effect
SUMMARY OBJECTIVE: We aimed to determine whether vitamin C has a protective effect on cisplatin-induced neuropathy in rats. METHODS: In total, 24 rats were included in the study of which 8 rats (no drug administered) were categorized as the control group. The remaining 16 rats were given a total dose of 20 mg/kg cisplatin to induce neuropathy. These drug-a
Revista da Associação Médica Brasileira. Publicado em: 2022
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5. Anti-Zika Virus Effects, Placenta Protection and Chemical Composition of Passiflora edulis Seeds Ethanolic Extract
Various beneficial biological activities have been reported for passion fruit (Passiflora edulis), grown in tropical and subtropical regions. However, no study has yet demonstrated its action against the Zika virus (ZIKV) infection. The present study aimed to investigate the anti-ZIKV of the ethanolic passion fruit seed extract (PFSE), from which, liquid chr
Journal of the Brazilian Chemical Society. Publicado em: 2022
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6. Biogenic synthesis of silver nanoparticles from thyme extract for functionalization of a bioactive glass produced from rice husk ash
Abstract The rice husk, agro-industrial residue, stands out for having silica, the main oxide former of the bioactive glass. To avoid contamination in this biomaterial, substances with bactericidal properties, like silver can be incorporated. Thus, the objective of this work is the synthesis of silver nanoparticles to functionalize a bioactive glass synthesi
Cerâmica. Publicado em: 2022
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7. Trypanocidal Activity and Increased Solubility of Benznidazole Incorporated in PEG 4000 and Its Derivatives
Selecting a polymer depends on its characteristics, the properties of the drug and of the remaining ingredients in the formulation. The drug, when incorporated into a polymeric matrix, can show several advantages when compared with its conventional form. In this context, this work describes the preparation and characterization of polyethylene glycol (PEG 400
J. Braz. Chem. Soc.. Publicado em: 2021-06
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8. Synthesis of Hydroxybenzodiazepines with Potential Antioxidant and Antifungal Action
Benzodiazepines derivatives are nitrogen heterocyclic compounds that have various industrial, synthetic, and medicinal applications. Therefore, its potential fully justifies every effort towards the improvement of new, selective, and competent production of these heterocyclic compounds. The novelty of this study encompasses the synthesis of new hydroxylated
J. Braz. Chem. Soc.. Publicado em: 2021-03
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9. INSECTICIDAL AND FUNGICIDAL ACTIVITY OF A MAGNESIUM COMPOUND CONTAINING ISOVANILLIC ACID AGAINST LEAF-CUTTING ANT AND ITS SYMBIOTIC FUNGUS
Pesticides offer a simple, cost-effective solution to ensure food supplies for a growing world population. However, their environmental performance needs improvement if pesticides are to continue contributing importantly. This study explores the insecticidal potential of a magnesium (II) metal complex containing 1,10-phenanthroline and isovanillic acid (MgPh
Quím. Nova. Publicado em: 2021-03
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10. ESTUDOS DE QSAR PARA SARS-CoV-2
The generation of mathematical models through the quantitative relationship between the chemical structure and the biological activity (QSARs) of compounds was used in this investigation. Mathematical models were generated from compounds available in literature that predicting the biological activity against SARS-CoV-2. The data indicate that the parameters
Quím. Nova. Publicado em: 2020-09
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11. Antifungal activity of selected plant extracts based on an ethnodirected study
ABSTRACT Plants have been reported as used by local populations to treat various infections for a long time, which has directed several pharmacological studies. The main aim of this work was to evaluate three plant selection criteria with better predictive power to detect extracts with antifungal action: (1) medicinal plants that are not used for indications
Acta Bot. Bras.. Publicado em: 2020-06
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12. System electro-neutralizer of agrochemicals contained in food and water samples through electrons trap
Abstract This study presents a system to electro-neutralize agrochemicals in food and water samples based on the properties of a controlled electron trap, the related apparatus is protected under patent application (WO/2018/090110; INPI: BR 10 2016 0268486) / (PCT / BR 2017/050115). The efficacy of the system was verified as to the type, quantity, surface te
Food Sci. Technol. Publicado em: 2020-06