3 Animal Models
Mostrando 1-12 de 489 artigos, teses e dissertações.
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1. Mongolian Gerbils as a Model for the Study of Cholesteatoma: Otoendoscopic as a Diagnostic Tool
Abstract Introduction Cholesteatoma is a disease with significant clinical impact but is incompletely understood. The challenge of performing studies with long-term follow-up in humans is a factor that has restricted the advance of knowledge in this field. Thus, the use of animal models is highly pertinent, and the Mongolian gerbil model has emerged as one
International Archives of Otorhinolaryngology. Publicado em: 2022
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2. Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3 inflammasome pathway in a mouse model
Abstract Vitamin D has been known to have important regulatory functions in inflammation and immune response and shows inhibitory effects on experimental periodontitis in animal models. However, the potential mechanism has yet to be clarified. Recent studies have highlighted Aryl hydrocarbon receptor (AhR) and its downstream signaling as a crucial regulator
J. Appl. Oral Sci.. Publicado em: 04/11/2019
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3. Genetic evaluation models for post-weaning weight gain in a multibreed Angus-Nelore population
Resumo: O objetivo deste trabalho foi identificar o modelo mais adequado para avaliação genética do ganho de peso pós-desmama em uma população multirracial de Angus-Nelore. Foram testados três modelos com uso do método de inferência bayesiana: animal tradicional (M1), animal multirracial sem (M2) e com segregação (M3). A escolha do melhor modelo s
Pesq. agropec. bras.. Publicado em: 29/08/2019
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4. Fascioliasis in buffaloes: A 5-year forecast analysis of the disease based on a 15-year survey in Brazil
Resumo Na América do Sul, a fasciolose causada pelo Trematoda Fasciola hepatica é uma antropozoonose associada a perdas econômicas significativas e baixo grau de bem-estar animal. O objetivo deste estudo foi determinar a prevalência de F. hepatica no fígado de búfalos abatidos entre 2003 a 2017 e realizar uma análise de previsão da doença para os pr
Rev. Bras. Parasitol. Vet.. Publicado em: 18/07/2019
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5. Efficacy of application of Equisetum pyramidale Goldm. hydrogel for tissue restoration of induced skin lesions in Wistar rats
Resumo As plantas medicinais, como E. pyramidale, são uma alternativa para combater infecções e ajudar o processo de cicatrização de feridas. Avaliar os efeitos do hidrogel de E. pyramidale na cicatrização de feridas cutâneas em modelos animais através de análises morfológicas, morfométricas e histológicas, bem como para elucidar os principais c
Braz. J. Biol.. Publicado em: 09/05/2019
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6. 18F-FDG PET/CT AS AN ASSESSMENT TOOL OF HEPATOCELLULAR CARCINOMA SECONDARY TO NON-ALCOHOLIC FATTY LIVER DISEASE DEVELOPMENT IN EXPERIMENTAL MODEL
RESUMO BACKGROUND: O carcinoma hepatocelular (CHC) pode ser a última fase da doença hepática gordurosa não alcoólica (DHGNA). Modelos experimentais são cruciais para elucidação da patogênese do CHC secundário a DHGNA. A tomografia por emissão de pósitrons/tomografia computadorizada (PET/TC) com 2-desoxi-2-(18F)fluoro-D-glicose (18F-FDG) desempe
Arq. Gastroenterol.. Publicado em: 18/03/2019
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7. Frequency and factors associated with Theileria equi, Babesia caballi and Trypanosoma evansi in equids from Bahia (Northeast Brazil)
Resumo Este estudo teve como objetivos conhecer a frequência e os fatores associados à infecção por Babesia caballi, Theileria equi e Trypanosoma evansi em equinos naturalmente infectados do nordeste do Brasil. Amostras de sangue de 569 equídeos (528 equinos, 8 muares e 33 asininos) foram coletadas e testadas para a presença do DNA destes parasitos at
Rev. Bras. Parasitol. Vet.. Publicado em: 14/02/2019
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8. Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study
The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was
Braz J Med Biol Res. Publicado em: 24/01/2019
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9. Voluntary wheel running: patterns and physiological effects in mice
Exercise can prevent and improve the pathophysiology of diseases and promote healthy aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise may lead to the development of new strategies to enhance quality of life and to counteract chronic diseases. Voluntary wheel running is an interesting model to study the effects of exe
Braz J Med Biol Res. Publicado em: 10/12/2018
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10. Anxiolytic properties of compounds that counteract oxidative stress, neuroinflammation, and glutamatergic dysfunction: a review
Objective: Anxiety disorders are highly prevalent and the efficacy of the available anxiolytic drugs is less than desired. Adverse effects also compromise patient quality of life and adherence to treatment. Accumulating evidence shows that the pathophysiology of anxiety and related disorders is multifactorial, involving oxidative stress, neuroinflammation,
Braz. J. Psychiatry.. Publicado em: 11/10/2018
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11. Adrenergic receptor β3 is involved in the memory consolidation process in mice
Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends o
Braz J Med Biol Res. Publicado em: 06/08/2018
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12. The mechanism of drug interactions of a selected antiarrhythmic drug with metformin, in different animal models
ABSTRACT This study was carried out to understand the influence of a selected antiarrhythmic drug on the pharmacodynamics and pharmacokinetics of an antidiabetic drug in animal models. Pharmacodynamic and pharmacokinetic responses were determined by measurements of blood glucose and serum insulin and serum metformin to drug interactions between disopyramide
Braz. J. Pharm. Sci.. Publicado em: 08/01/2018