1 2 3 Triazol
Mostrando 1-12 de 52 artigos, teses e dissertações.
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1. Synthesis of Eugenol-Fluorinated Triazole Derivatives and Evaluation of Their Fungicidal Activity
Eugenol (C10H12O2, 4-allyl-2-methoxyphenol) is a phenolic natural product that has several biological activities and possibilities of applications. It is herein described the synthesis of eugenol-fluorinated triazole derivatives and evaluation of their fungicidal activity. The reaction of eugenol with epichlorohydrin resulted in the preparation of (±)-2-((4
Journal of the Brazilian Chemical Society. Publicado em: 2022
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2. Inhibition of Acetylcholinesterase by Coumarin-Linked Amino Acids Synthetized via Triazole Associated with Molecule Partition Coefficient
A previous study for the identification of acetylcholinesterase (AChE) inhibitors demonstrated that the hybrid between tyrosol, the 1,2,3-triazole nucleus, and the coumarin group, namely 7-({1-[2-(4-hydroxyphenyl)ethyl]-1H-1,2,3-triazol-4-yl}methoxy)-4-methyl-2H-chromen-2-one (10), has a high enzyme inhibitory activity. Here, we synthesized analogues of 10 v
J. Braz. Chem. Soc.. Publicado em: 2021-03
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3. Synthesis of 1,2,3-Triazole Derivatives of Hydnocarpic Acid Isolated from Carpotroche brasiliensis Seed Oil and Evaluation of Antiproliferative Activity
Carpotroche brasiliensis is a tree native to Brazil, belonging to the family Flacurtiaceae, whose seeds contain a group of cyclopentenyl fatty acids: gorlic (12%), chaulmugric (27%), and hydnocarpic (48.7%). These compounds are considered the main therapeutic agents in the treatment of leprosy. In the present study, a series of novel triazole compounds were
J. Braz. Chem. Soc.. Publicado em: 2020-12
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4. Streamlined Synthesis of 6-((1H-1,2,3-Triazol-4-yl)methyl)-1H-pyrrolo [3,4-d]pyridazin-1-one System via Sequential N-Alkylation, CuAAC, and [4 + 2] Cyclization Reactions
An efficient sequential three-step reaction methodology for the synthesis of three new series-1-(prop-2-yn-1-yl)-1H-pyrroles, methyl 4-acetyl-1-((1H-1,2,3-triazol-4-yl)methyl)-1H-pyrrole-3-carboxylates and 6-((1H-1,2,3-triazol-4-yl)methyl)-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-1-ones-is reported. The methodology comprises: (i) N-alkylation reactions of poly
J. Braz. Chem. Soc.. Publicado em: 23/05/2019
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5. Synthesis of 1,2,3-Triazole Derivatives of 4,4'-Dihydroxybenzophenone and Evaluation of Their Elastase Inhibitory Activity
The present investigation describes the synthesis of a series of novel triazole derivatives from 4,4'-dihydroxybenzophenone along with their elastase inhibitory activity. The 1,2,3-triazoles were obtained via the copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), also known as click reaction, between bis(4-(prop-2-yn-1-yloxy))benzophenone and s
J. Braz. Chem. Soc.. Publicado em: 2019-01
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6. Studies on new substituted pyridazinones: synthesis and biological evaluation
We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents. The title compounds were prepared by reacting 6-aryl-4,5-dihydro-(2H)-pyridazin-3-one (2a-e) with formaldehyde and secondary cyclic
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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7. Synthesis and Cytotoxic Evaluation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones
ABSTRACT The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been pointed out as efficient compounds in anticancer activity studies. Thus, a series of eleven 1,2-naphthoquinones tethered in C2 to 1,2,3-1H-triazoles 9a-k were designed, synthesized and their cyto
An. Acad. Bras. Ciênc.. Publicado em: 15/02/2018
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8. Strategies for Molecular Diversification of 2-[Aminoalkyl-(1H-1,2,3-triazol-1- yl)]-1,4-naphthoquinones Using Click Chemistry
Click chemistry-based strategies for the synthesis of 2-amino-alkyl-1,2,3-triazole-1,4-naphthoquinone derivatives make it possible to obtain desired products from 1,4-naphthoquinone (1,4-NQ), and bio-based lawsone, nor-lapachol and lapachol. The first route (Strategy A) starting from 1,4-NQ and amino alcohols, then 2-amino-alkyl-1,4-NQ alcohols, were tosylat
J. Braz. Chem. Soc.. Publicado em: 2017-04
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9. Crystal Structures of 1-Aryl-1H- and 2-Aryl-2H-1,2,3-triazolyl Hydrazones. Conformational Consequences of Different Classical Hydrogen Bonds
The crystal structures of (Z)-1-phenyl-4-[((2-phenylhydrazono)methyl)]-1H-1,2,3-triazole, (Z)-4-[(2-(2,4-dimethylphenyl)hydrazono)methyl]-2-phenyl-2H-1,2,3-triazole, (E)-4-[(2-(2,4-dinitrophenyl)hydrazono)methyl]-2-phenyl-2H-1,2,3-triazole, and (E)-N'-((2-phenyl-2H-1,2,3-triazol-4-yl)methylene)isonicotinohydrazide dihydrate are reported. The formations of (Z
J. Braz. Chem. Soc.. Publicado em: 2016-12
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10. In vitro Anti-HMPV Activity of New Synthetic Phenytoin Derivatives
New derivatives of synthetic 5,5-diphenylhydantoin (phenytoin) were prepared by N-alkylation with 1,3-dibromopropane. Subsequent treatment with sodium azide led to the respective azide. Reaction of the azide with phenylacetylene and 2-hydroxy-3-butyne and oxidation of the resulting alcohol with MnO2 resulted in three triazolic compounds that were evaluated i
J. Braz. Chem. Soc.. Publicado em: 2016-01
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11. Synthesis of 3-(1H-1,2,3-Triazol-1-yl)-2-(arylselanyl)pyridines by Copper-Catalyzed 1,3-Dipolar Cycloaddition of 2-(Arylselanyl)-3-azido-pyridines with Terminal Alkynes
We present here our results in the synthesis of eleven new 3-(1H-1,2,3-triazol-1-yl)-2-(arylselanyl)pyridines by copper-catalyzed azide-alkyne cycloaddition reactions. The reactions were performed in the presence of catalytic amount of copper(II) acetate and sodium ascorbate using a mixture of tetrahydrofuran/water (1:1) as solvent at room temperature in air
J. Braz. Chem. Soc.. Publicado em: 2015-11
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12. Chromatographic and Calculation Methods for Analysis of the Lipophilicity of Newly Synthesized Thiosemicarbazides and their Cyclic Analogues 1,2,4-Triazol-3-thiones
This paper describes the evaluation of the lipophilicity of newly synthesized thiosemicarbazides and their cyclic analogues 1,2,4-triazol-3-thiones obtained using experimental and calculated methods. Previous studies have shown these compounds have antibacterial activity. The chromatographic behavior of analyzed compounds was studied by reversed phase hig
J. Braz. Chem. Soc.. Publicado em: 2015-08